Ammonia → 1-Methyl-4-bromo-5-aminobenzimidazole

HRID 429552ノート

反応式

HRID 429552 の反応式
[CH3:1][N:2]1[C:6]2[CH:7]=[CH:8][C:9]([NH2:11])=[CH:10][C:5]=2[N:4]=[CH:3]1.[Br:12]Br.N>CC(O)=O>[CH3:1][N:2]1[C:6]2[CH:7]=[CH:8][C:9]([NH2:11])=[C:10]([Br:12])[C:5]=2[N:4]=[CH:3]1

参加物

5

反応物 3

HCID 222AmmoniaHCID 24408BromineHCID 3154991-methyl-1H-1,3-benzodiazol-5-amine

生成物 1

HCID 129684511-Methyl-4-bromo-5-aminobenzimidazole収率 50%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

反応条件

温度
25 °C

実験手順

1-methyl-5-aminobenzimidazole (0.36 g, 2.4 mmol) in 10 ml of AcOH was added Br2 (0.12 ml). The reaction mixture was stirred for 1 h at 25° C. and concentrated in vacuo, yielding an oil which was subjected to column chromatography (NH3 sat'd 3% MeOH/CHCl3) to yield 0.27 g (1.2 mmol, 50%) of the desired product.

後処理

  1. concentrationconcentrated in vacuo
  2. customyielding an oil which

出典と根拠

ORDレコード
ord-988bc22c2ab84888860fa2343a3f5991
出典データセット
uspto-grants-2001_11
特許番号
US06316637B1

反応ノート

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