Ammonia → 3-Methyl-4-bromo-5-aminobenzimidazole

HRID 429553

反応式

HRID 429553 の反応式
[CH3:1][N:2]1[C:6]2[CH:7]=[C:8]([NH2:11])[CH:9]=[CH:10][C:5]=2[N:4]=[CH:3]1.[Br:12]Br.N>CC(O)=O>[CH3:1][N:2]1[C:6]2[C:7]([Br:12])=[C:8]([NH2:11])[CH:9]=[CH:10][C:5]=2[N:4]=[CH:3]1

参加物

5

反応物 3

HCID 222AmmoniaHCID 24408BromineHCID 136802831-Methyl-1H-benzimidazol-6-amine

生成物 1

HCID 129684523-Methyl-4-bromo-5-aminobenzimidazole収率 35%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

反応条件

温度
25 °C

実験手順

To a solution of 3-methyl-5-aminobenzimidazole (0.27 g, 1.8 mmol) in 10 ml of AcOH was added Br2 (0.10 ml). The reaction mixture was stirred for 1 h at 25° C. and concentrated in vacuo, yielding an oil which was subjected to column chromatography (NH3 sat'd 3% MeOH/CHCl3) to yield 0.14 g (0.62 mmol, 35%) of the desired product.

後処理

  1. concentrationconcentrated in vacuo
  2. customyielding an oil which

出典と根拠

ORDレコード
ord-df82cdfd8d904547af74871b1b81e30c
出典データセット
uspto-grants-2001_11
特許番号
US06316637B1

関連ノート

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