Bromine → HCID 178432201、化合物
反応式
[CH3:1][C:2]1[NH:3][C:4]2[CH:10]=[C:9]([NH2:11])[CH:8]=[CH:7][C:5]=2[N:6]=1.[Br:12]Br>CC(O)=O>[CH3:1][C:2]1[NH:3][C:4]2[C:10]([Br:12])=[C:9]([NH2:11])[CH:8]=[CH:7][C:5]=2[N:6]=1参加物
4
反応条件
- 温度
- 25 °C
実験手順
To a solution of 0.9 g (6.1 mmol) of 2-methyl-5-aminobenzimidazole in 50 ml of AcOH was added 0.16 ml of Br2 (3.1 mmol) dropwise and resulting reaction mixture was stirred for 1 h at 25° C. Reaction mixture was concentrated in vacuo and purified on silica gel column chromatography (20% Isopropanol/EtOAC) to yield 0.56 g (2.5 mmol, 41%) of the desired product.
後処理
- customresulting
- customreaction mixture
- customReaction mixture
- concentrationwas concentrated in vacuo
- custompurified on silica gel column chromatography (20% Isopropanol/EtOAC)
出典と根拠
- ORDレコード
- ord-a5e972421d32405c80f8d552a3f68e86
- 出典データセット
- uspto-grants-2001_11
- 特許番号
- US06316637B1
反応ノート
読み込み中…