Bromine → 2-Cyclopropyl-4-bromo-5-aminobenzimidazole
反応式
[CH:1]1([C:4]2[NH:5][C:6]3[CH:12]=[C:11]([NH2:13])[CH:10]=[CH:9][C:7]=3[N:8]=2)[CH2:3][CH2:2]1.[Br:14]Br>CC(O)=O>[CH:1]1([C:4]2[NH:5][C:6]3[C:12]([Br:14])=[C:11]([NH2:13])[CH:10]=[CH:9][C:7]=3[N:8]=2)[CH2:3][CH2:2]1参加物
4
反応条件
- 温度
- 25 °C
実験手順
To a solution of 0.87 g (4.9 mmol) of 2-cyclopropyl-5-aminobenzimidazole in 50 ml of AcOH was added 0.10 ml (1.9 mmol) of Br2 dropwise and resulting reaction mixture was stirred for 1 h at 25° C. The reaction mixture was concentrated in vacuo and purified on silica gel column chromatography (5% MeOH/EtOAC) to yield 0.42 g (1.8 mmol, >95%) of the desired product.
後処理
- customresulting
- customreaction mixture
- concentrationThe reaction mixture was concentrated in vacuo
- custompurified on silica gel column chromatography (5% MeOH/EtOAC)
出典と根拠
- ORDレコード
- ord-1b47647b715b49dbb21d6b3eb93d4a51
- 出典データセット
- uspto-grants-2001_11
- 特許番号
- US06316637B1
反応ノート
読み込み中…