Dicyclohexylcarbodiimide → Retinamide

HRID 429588

反応式

HRID 429588 の反応式
C1([N:7]=C=NC2CCCCC2)CCCCC1.[CH3:16][C:17]1[CH2:22][CH2:21][CH2:20][C:19]([CH3:24])([CH3:23])[C:18]=1/[CH:25]=[CH:26]/[C:27](/[CH3:37])=[CH:28]/[CH:29]=[CH:30]/[C:31](/[CH3:36])=[CH:32]/[C:33](O)=[O:34].ON1C2C=CC=CC=2N=N1>ClCCl>[CH3:16][C:17]1[CH2:22][CH2:21][CH2:20][C:19]([CH3:24])([CH3:23])[C:18]=1/[CH:25]=[CH:26]/[C:27](/[CH3:37])=[CH:28]/[CH:29]=[CH:30]/[C:31](/[CH3:36])=[CH:32]/[C:33]([NH2:7])=[O:34]

参加物

5

反応物 3

HCID 10868DicyclohexylcarbodiimideHCID 757711-HydroxybenzotriazoleHCID 444795Retinoic Acid

生成物 1

HCID 5370221Retinamide収率 62%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

3 g (0.0146 mole) of dicyclohexylcarbodiimide (DCC) was added to the solution of 4.48 g (0.0112 mole) of 1-amino-polyethylene glyco (molecular weight 400), 3.98 g (0.0133 mole) of retinoic acid and 1.51 g (0.0112 mole) of 1 -hydroxybenzotriazole in 40 ml of dry dichloromethane, and the reaction solution was then treated according to the same procedure as described in Example 1(A) to obtain the title compound (Yield 62%, Tm=−14° C., Rf=0.15).

後処理

  1. additionthe reaction solution was then treated

出典と根拠

ORDレコード
ord-b24423e0eff84616a3d65f696c31a5ff
出典データセット
uspto-grants-2001_11
特許番号
US06316644B1

関連ノート

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