Chloroacetone → 8-(2-Methylbenzylamino)-2-methylimidazo[1,2-a]pyridine

HRID 4296

反応式

HRID 4296 の反応式
[NH2:1][C:2]1[C:7]([NH:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[CH3:16])=[CH:6][CH:5]=[CH:4][N:3]=1.Cl[CH2:18][C:19](=O)[CH3:20]>C(O)C>[CH3:16][C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=1[CH2:9][NH:8][C:7]1[C:2]2[N:3]([CH:18]=[C:19]([CH3:20])[N:1]=2)[CH:4]=[CH:5][CH:6]=1

参加物

4

反応物 2

HCID 6571ChloroacetoneHCID 138258912-Amino-3-(2-methylbenzylamino)pyridine

生成物 1

HCID 201523218-(2-Methylbenzylamino)-2-methylimidazo[1,2-a]pyridine

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of 2-amino-3-(2-methylbenzylamino)pyridine (3.25 g) and chloroacetone (1.26 ml) in ethanol (65 ml) was refluxed for 18 hours and then evaporated in vacuo. To the residue was added aqueous sodium bicarbonate solution and the mixture was extracted with methylene chloride. The extract was washed with brine, dried over magnesium sulfate, and evaporated in vacuo. The oily residue was purified by column chromatography on silica gel (40 g) with a mixture of methylene chloride and ethyl acetate (10:1) as an eluent to give 8-(2-methylbenzylamino)-2-methylimidazo[1,2-a]pyridine (1.80 g).

後処理

  1. customevaporated in vacuo
  2. additionTo the residue was added aqueous sodium bicarbonate solution
  3. extractionthe mixture was extracted with methylene chloride
  4. washThe extract was washed with brine
  5. dry with materialdried over magnesium sulfate
  6. customevaporated in vacuo
  7. customThe oily residue was purified by column chromatography on silica gel (40 g) with a mixture of methylene chloride and ethyl acetate (10:1) as an eluent

出典と根拠

ORDレコード
ord-022e022fa6a34c4ca3ba0dec5c804a5d
出典データセット
uspto-grants-1988_02
特許番号
US04725601

関連ノート

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