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Phosgen toluene → 2-(4-methoxyphenyl-1-methylethyl]-N-ethyl-(1-chlorocarbonylpiperidin-4-ylmethyl)amine hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phosgen toluene | HCID 19083224 | — |
| 反応物 | 2-(4-methoxyphenyl-1-methylethyl]-N-ethyl-(piperidin-4-ylmethyl)amine | HCID 86757605 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 2-(4-methoxyphenyl-1-methylethyl]-N-ethyl-(1-chlorocarbonylpiperidin-4-ylmethyl)amine hydrochloride | HCID 86757603 | 77.4% |
反応手順
To a solution of 2 M phosgene/toluene (2.0 ml, 4 mmole) in ethyl ether (20 ml) was added a solution of N-[2-(4-methoxyphenyl-1-methylethyl]-N-ethyl-(piperidin-4-ylmethyl)amine (0.23 grams, 0.79 mmole) in ethyl ether (30 ml). After 30 minutes the precipitate was collected by filtration and dried in vacuo to give N-[2-(4-methoxyphenyl-1-methylethyl]-N-ethyl-(1-chlorocarbonylpiperidin-4-ylmethyl)amine hydrochloride (0.238 grams, 77%), m.p. 144-145° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06319920B1 |
| 出典データセット | uspto-grants-2001_11 |
| ORD ID | ord-1ec6e23dc6ff4907bd35a8ee02bb9891 |
| 出典メモ | uspto-grants-2001_11 |