Phosphoric Acid → (s)-n-[2-(2,3,-Dihydrobenzofuran-5-yl)-1-methylethyl]-n-ethyl-(1-methanesulfonylpiperidin-4-ylmethyl)amine phosphate
反応式
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH2:10][C@@H:11]([N:13]([CH2:16][CH:17]3[CH2:22][CH2:21][N:20]([S:23]([CH3:26])(=[O:25])=[O:24])[CH2:19][CH2:18]3)[CH2:14][CH3:15])[CH3:12])=[CH:9][C:4]=2[CH2:3][CH2:2]1.[P:27](=[O:31])([OH:30])([OH:29])[OH:28]>C(O)C>[P:27]([OH:31])([OH:30])([OH:29])=[O:28].[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH2:10][C@@H:11]([N:13]([CH2:16][CH:17]3[CH2:22][CH2:21][N:20]([S:23]([CH3:26])(=[O:24])=[O:25])[CH2:19][CH2:18]3)[CH2:14][CH3:15])[CH3:12])=[CH:9][C:4]=2[CH2:3][CH2:2]1参加物
4
反応物 2
生成物 1
試薬・触媒・溶媒 1
実験手順
(S)-N-[2-(2,3,-Dihydrobenzofuran-5-yl)-1-methylethyl]-N-ethyl-(1-methanesulfonylpiperidin-4-ylmethyl)amine (0.4 grams, 1.05 mmole) was dissolved in (10 ml) hot 10% aqueous ethanol. To this solution was added 85% phosphoric acid (0.122 grams, 1.06 mmole). The solution was stored at 22° C. for 16 hours. The deposited crystals were collected and dried in vacuo at 70° C. to give (S)-N-[2-(2,3,-dihydrobenzofuran-5-yl)-1-methylethyl]-N-ethyl-(1-methanesulfonylpiperidin-4-ylmethyl)amine phosphate (0.454 grams, 97%), m.p. 209-210° C.