2,4-Di-tert-butylphenol → 2-Bromo-4,6-di-tert-butylphenol

HRID 429945ノート

反応式

HRID 429945 の反応式
[C:1]([C:5]1[CH:10]=[C:9]([C:11]([CH3:14])([CH3:13])[CH3:12])[CH:8]=[CH:7][C:6]=1[OH:15])([CH3:4])([CH3:3])[CH3:2].[Br:16]Br>>[Br:16][C:7]1[CH:8]=[C:9]([C:11]([CH3:14])([CH3:13])[CH3:12])[CH:10]=[C:5]([C:1]([CH3:4])([CH3:3])[CH3:2])[C:6]=1[OH:15]

参加物

3

反応物 2

HCID 73112,4-Di-tert-butylphenolHCID 24408Bromine

生成物 1

HCID 5198222-Bromo-4,6-di-tert-butylphenol収率 91.8%

実験手順

To a solution of 2,4-di-t-butylphenol (Aldrich, 2.0 g, 9.7 mmol) in 2 ml of HOAC was added Br2 (0.5 ml, 9.7 mmol). The reaction mixture was stirred at room temperature for 12 hours. Solvent was removed under reduced pressure and the residue was purified by column chromatography (ethyl acetate/hexane 1/20) to yield the desired product (2.54 g) as a white solid.

後処理

  1. customSolvent was removed under reduced pressure
  2. customthe residue was purified by column chromatography (ethyl acetate/hexane 1/20)

出典と根拠

ORDレコード
ord-7fed9cd228f34ef19a46051c6ee2e031
出典データセット
uspto-grants-2001_11
特許番号
US06320047B1

反応ノート

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