Potassium Cyanide → 1,3-Dioxolane-2-propiononitrile

HRID 429959ノート

反応式

HRID 429959 の反応式
Cl[CH2:2][CH2:3][CH2:4][CH:5]1[O:9][CH2:8][CH2:7][O:6]1.[C-]#[N:11].[K+]>CS(C)=O.O>[O:6]1[CH2:7][CH2:8][O:9][CH:5]1[CH2:4][CH2:3][C:2]#[N:11]

参加物

5

反応物 2

HCID 9032Potassium CyanideHCID 5520722-(3-Chloropropyl)-1,3-dioxolane

生成物 1

HCID 780981,3-Dioxolane-2-propiononitrile収率 43.7%

試薬・触媒・溶媒 2

HCID 679Dimethyl Sulfoxide溶媒HCID 962Water溶媒

反応条件

温度
100 °C

実験手順

A mixture of 2-(3-chloropropyl)-1,3-dioxolane (5.7 g, 37.8 mmol) and potassium cyanide (3.8 g, 58.4 mmol) in dimethylsulfoxide (12 mL) was heated at 100° C. for 48 hours. The reaction mixture was diluted with water (80 mL) and extracted with ether (3×60 mL). The combined ether layer was washed with water (3×60 mL), dried (magnesium sulfate), concentrated in vacuo and purified by silica gel chromatography (ethyl acetate in hexane, 1:2) to afford the title compound (2.1 g, 40%) as a pale yellow liquid;

後処理

  1. extractionextracted with ether (3×60 mL)
  2. washThe combined ether layer was washed with water (3×60 mL)
  3. dry with materialdried (magnesium sulfate)
  4. concentrationconcentrated in vacuo
  5. custompurified by silica gel chromatography (ethyl acetate in hexane, 1:2)

出典と根拠

ORDレコード
ord-57dd812a0d2f4c448710438e78ce82f1
出典データセット
uspto-grants-2001_11
特許番号
US06319946B1

反応ノート

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