[C:1]([C:4]1[C:5]2[CH:12]=[C:11]([O:13][S:14]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)(=[O:16])=[O:15])[CH:10]=[CH:9][C:6]=2[S:7][CH:8]=1)(=[O:3])C.C1(S(OC2C=CC(SCC#C)=CC=2)(=O)=[O:30])C=CC=CC=1.Cl[O-].[Na+].Cl>O1CCOCC1>[C:17]1([S:14]([O:13][C:11]2[CH:10]=[CH:9][C:6]3[S:7][CH:8]=[C:4]([C:1]([OH:30])=[O:3])[C:5]=3[CH:12]=2)(=[O:15])=[O:16])[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1The compound (9) (6.65 g, 20 mmol) prepared in above (2) was dissolved in dioxane (50 ml), and 10% sodium hypochlorite (46.2 ml) was added over 20 minutes with stirring while maintaining the temperature at 10-12° C. After 7 hours, the reaction mixture was diluted with ice-water (80 ml) and acidified with conc. hydrochloric acid (5.2 ml). The deposited crystals were filtered, washed with water, dried to provide 5.84 g of crude crystals. The 5.84 g of the crude crystals were recrystallized from methanol (66 ml) and water (16 ml) to provide 5.51 g of the title compound (6). Yield: 82.4%. mp 203-204° C.
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