関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | Water | HCID 962 | — |
| 反応物 | 4-Bromo-5-nitrophthalide | HCID 18551185 | — |
| 触媒 | Ferrous Sulfate | HCID 24393 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 4-Bromo-5-aminophthalide | HCID 18551168 | 70.3% |
反応手順
6.6 g of 4-bromo-5-nitrophthalide is dissolved in 45 ml of ethanol and added in drops to a mixture of 65 g of iron(II) sulfate, 220 ml of water and 65 ml of ammonia (33%) that is heated to 60° C. and thoroughly stirred. After 2 hours at 60° C., the mixture is absorptively precipitated five times with 200 ml of diethyl ether. The diethyl ether phases are concentrated by evaporation. As a residue, 4.1 g of 4-bromo-5-aminophthalide is obtained, flash point 176-180° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06323199B1 |
|---|
| 出典データセット | uspto-grants-2001_11 |
|---|
| ORD ID | ord-01241adb8b4647fabe5ad1922a7e6b1c |
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| 出典メモ | uspto-grants-2001_11 |
|---|
