化工社化工社 化学情報印刷レポート · 研究参考用
Glyoxal → 5,8-Dibromoquinoxaline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Glyoxal | HCID 7860 | — |
| 反応物 | 3,6-Dibromobenzene-1,2-diamine | HCID 11821532 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 5,8-Dibromoquinoxaline | HCID 11514763 | 79.5% |
反応手順
A 40% aqueous solution of glyoxal (8.8 M, 6.3 mL, 55.1 mmol, 1.3 equiv) was added to a suspension of 3,6-dibromo-benzene-1,2-diamine (Step 1.6) (11.3 g, 42.4 mmol) in EtOH (280 mL). The reaction mixture was heated to reflux for 3 h and allowed to cool to rt overnight. Vacuum filtration of the reaction mixture afforded 9.7 g of the title compound as a yellow solid: APCI-MS: 286.2/288.1/290.1 [M−1]−; tR=4.40 min (System 1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08536175B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-3752f261596140a6bdbe69df656e39c9 |
| 出典メモ | uspto-grants-2013_09 |