化工社化工社 化学情報印刷レポート · 研究参考用
2,4-Hexadienoic Acid → N-[4-(3-Bromoanilino)quinazolin-6-yl]hexa-2,4-dienamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2,4-Hexadienoic Acid | HCID 5251 | — |
| 反応物 | 4-Methylmorpholine | HCID 7972 | — |
| 反応物 | Isobutyl chloroformate | HCID 62365 | — |
| 反応物 | N4-(3-Bromophenyl)quinazoline-4,6-diamine | HCID 5328042 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | N-[4-(3-Bromoanilino)quinazolin-6-yl]hexa-2,4-dienamide | HCID 53794091 | 48.1% |
反応手順
A solution of 0.67g of 2,4-hexadienoic acid in 10 ml of tetrahydrofuran was cooled in an ice bath. A 0.79 ml portion of isobutyl chloroformate followed by a 0.66 ml portion of N-methyl morpholine were added. After about 1 minute a solution of 1.6 g of N-(3-bromophenyl)-4,6-quinazolindiamine in 10 ml of pyridine was added. The reaction was allowed to come to room temperature and stir overnight. The solvents were removed at reduced pressure and the solid was recrystallized to give 1.0 g of N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]-2,4-hexadienamide: mp=258-260° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06323209B1 |
| 出典データセット | uspto-grants-2001_11 |
| ORD ID | ord-dae111710f8f43aba1850e3b195cf321 |
| 出典メモ | uspto-grants-2001_11 |