関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | m-Toluidine | HCID 7934 | — |
| 反応物 | Diethyl (ethoxymethyl)malonate | HCID 98702 | — |
| 溶媒 | 1,1'-Biphenyl, mixt. with 1,1'-oxybis(benzene) | HCID 24670 | — |
| 生成物 | Ethyl 7-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylate | HCID 178469524 | 76.3% |
反応手順
Diethyl ethoxymethylmalonate (37.8 mL, 187 mmol) and m-toluidine (20.0 mL, 187 mmol) were combined and heated at 100° C. for about 3 hours. The reaction mixture was allowed to cool to ambient temperature and it solidified. Dowtherm A (350 mL) was added and the reaction mixture was heated at reflux for about 30 minutes. The reaction mixture was allowed to cool to ambient temperature. The resulting precipitate was isolated by filtration, rinsed with acetone and dried to provide 33 g of ethyl 4-hydroxy-7-methyl-3-quinolinecarboxylate as a tan powder.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06323200B1 |
|---|
| 出典データセット | uspto-grants-2001_11 |
|---|
| ORD ID | ord-1ea39f341a784220968943198e07225e |
|---|
| 出典メモ | uspto-grants-2001_11 |
|---|
