Methyl 3-bromo-2,4,5-trifluorobenzoate → Methyl 3-cyano-2,4,5-trifluoro-benzoate

HRID 430591ノート

反応式

HRID 430591 の反応式
Br[C:2]1[C:3]([F:14])=[C:4]([CH:9]=[C:10]([F:13])[C:11]=1[F:12])[C:5]([O:7][CH3:8])=[O:6].[Cu][C:16]#[N:17]>CN(C)C=O>[C:16]([C:2]1[C:3]([F:14])=[C:4]([CH:9]=[C:10]([F:13])[C:11]=1[F:12])[C:5]([O:7][CH3:8])=[O:6])#[N:17]

参加物

4

反応物 2

HCID 18459836Methyl 3-bromo-2,4,5-trifluorobenzoateHCID 178418546HCID 178418546、化合物

生成物 1

HCID 18417526Methyl 3-cyano-2,4,5-trifluoro-benzoate収率 61.8%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A mixture of 269 g of methyl 3-bromo-2,4,5-trifluorobenzoate, 108 g of copper(I) cyanide and 400 ml of dimethylformamide is heated under reflux for 5 hours. All volatile components are distilled off in vacuo. Fractional distillation of the resulting mixture gives 133 g of the title compound.

後処理

  1. temperatureis heated
  2. temperatureunder reflux for 5 hours
  3. distillationAll volatile components are distilled off in vacuo
  4. distillationFractional distillation of the resulting mixture

出典と根拠

ORDレコード
ord-88c4248f374b4852b39ecf0afe36429e
出典データセット
uspto-grants-2001_11
特許番号
US06323213B1

反応ノート

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