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HRID 430654作成日：2026年10月26日
Butyrohydrazide → 9-Bromo-6-(4-nitrophenyl)-8-methoxy-3-propyl-11h-[1,2,4]triazolo[4,3-c][2,3]benzodiazepine
https://huagongshe.com/reaction/430654
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Butyrohydrazide | HCID 77079 | — |
| 反応物 | 7-Bromo-8-methoxy-4-methylthio-1-(4-nitrophenyl)-5h-2,3-benzodiazepine | HCID 18183198 | — |
| 触媒 | Hydrochloric Acid | HCID 313 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 9-Bromo-6-(4-nitrophenyl)-8-methoxy-3-propyl-11h-[1,2,4]triazolo[4,3-c][2,3]benzodiazepine | HCID 18183189 | 83% |
反応手順
1.17 g (2.78 mmol) of the compound of step B is dissolved in 40 ml of anhydrous DMF and mixed with 0.73 g (8.4 mmol) of butyric acid hydrazide as well as 3 drops of concentrated HCl. The mixture is stirred for 5 hours at 110-115° C. Then, the mixture is poured onto ice (160 g) and stirred for 1 more hour. The precipitated crystals are suctioned off and washed with water. 1.05 g (83%) of 9-bromo-6-(4-nitrophenyl)-8-methoxy-3-propyl-11H-[1,2,4]triazolo(4,3-c][2,3]benzodiazepine with a melting point of 238-240° C. is obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US06323197B1 |
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| 出典データセット | uspto-grants-2001_11 |
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| ORD ID | ord-728f87f35c844e35992bb1586774ce43 |
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| 出典メモ | uspto-grants-2001_11 |
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