化工社化工社 化学情報印刷レポート · 研究参考用
Isoquinoline-4-boronic acid → 8-Isoquinolin-4-yl-quinoxaline-5-carboxylic acid [3-(4-ethyl-piperazin-1-yl)phenyl]-amide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Isoquinoline-4-boronic acid | HCID 3761204 | — |
| 反応物 | 3-(4-Ethylpiperazin-1-yl)aniline | HCID 22330105 | — |
| 反応物 | 8-Isoquinolin-4-yl-quinoxaline-5-carboxylic acid | HCID 66914512 | — |
| 生成物 | 8-Isoquinolin-4-yl-quinoxaline-5-carboxylic acid [3-(4-ethyl-piperazin-1-yl)phenyl]-amide | HCID 44515669 | — |
反応手順
The title compound was prepared in analogy to the procedure described in Step 14.1 but using 3-(4-ethylpiperazin-1-yl)-aniline (Step 2.1) and 8-isoquinolin-4-yl-quinoxaline-5-carboxylic acid. The latter compound was synthesized as described in Steps 1.2-1.7 but using 4-isoquinolineboronic acid in Step 1.4. Title compound: ESI-MS: 489.2 [M+H]+; tR=11.28 min (System 2).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08536175B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-52ef3b22410d44a3bc3e8ff2635df5e4 |
| 出典メモ | uspto-grants-2013_09 |