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2,6-Dimethylphenylboronic acid → 8-(2,6-Dimethyl-phenyl)-Quinoxaline-5-carboxylic acid [3-(4-ethyl-piperazin-1-yl)phenyl]-amide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2,6-Dimethylphenylboronic acid | HCID 583322 | — |
| 反応物 | 3-(4-Ethylpiperazin-1-yl)aniline | HCID 22330105 | — |
| 反応物 | 8-(2,6-Dimethyl-phenyl)quinoxaline-5-carboxylic acid | HCID 66914574 | — |
| 触媒 | HCID 178418397 | HCID 178418397 | — |
| 生成物 | 8-(2,6-Dimethyl-phenyl)-Quinoxaline-5-carboxylic acid [3-(4-ethyl-piperazin-1-yl)phenyl]-amide | HCID 44516604 | — |
反応手順
The title compound was prepared in analogy to the procedure described in Step 14.1 but using 3-(4-ethylpiperazin-1-yl)-aniline (Step 2.1) and 8-(2,6-dimethyl-phenyl)-quinoxaline-5-carboxylic acid. The carboxylic acid was synthesized as described in Steps 1.2-1.7 but using 2,6-dimethylphenylboronic acid and Pd(PPh3)4 in Step 1.4. Title compound: ESI-MS: 466.2 [M+H]+; tR=3.74 min (System 3).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08536175B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-8ef091607c92475f8abcdd37192b7dee |
| 出典メモ | uspto-grants-2013_09 |