化工社化工社 化学情報印刷レポート · 研究参考用
N-Methylbenzylamine → 4-(N-benzyl-N-methyl-amino)-dihydro-furan-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-Methylbenzylamine | HCID 7669 | — |
| 反応物 | 2(5H)-Furanone | HCID 10341 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 4-(N-benzyl-N-methyl-amino)-dihydro-furan-2-one | HCID 69955135 | — |
反応手順
23.20 ml of N-methylbenzylamine are added to 15.00 g of 5H-furan-2-one in 150 ml methylene chloride. The reaction mixture is stirred for about 48 hours at ambient temperature. For working up the reaction mixture is concentrated by evaporation and chromatographed in batches over a silica gel column with ethyl acetate/petroleum ether (3:1) as eluant. The desired product is obtained as a yellowish oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06656946B2 |
| 出典データセット | uspto-grants-2003_12 |
| ORD ID | ord-af25213858bc4f09848fe3319cfce942 |
| 出典メモ | uspto-grants-2003_12 |