関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | 3-(Trifluoromethyl)phenol | HCID 7376 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 1-Chloro-2,5-dimethyl-4-nitrobenzene | HCID 252793 | — |
| 溶媒 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 生成物 | 1,4-Dimethyl-2-nitro-5-[3-(trifluoromethyl)phenoxy]benzene | HCID 15540071 | — |
反応手順
To a suspension of sodium hydride (0.4 g of 60% in oil) in dry N-methylpyrroli-dinone (10 ml) was slowly added 3-trifluoromethylphenol (1.62 g). When effervescence had ceased, 3-chloro-6-nitro-p-xylene (1.85 g) was added and the mixture stirred at 120-40° C. for 5 hours. On cooling, the mixture was poured into water and the mixture extracted with diethyl ether (x3). The combined ether extracts were dried (MgSO4), filtered and evaporated to give the title compound as a solid, m.p. 68-71° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06656967B2 |
|---|
| 出典データセット | uspto-grants-2003_12 |
|---|
| ORD ID | ord-f250edac67b04269b8718383f2b709f6 |
|---|
| 出典メモ | uspto-grants-2003_12 |
|---|
