4-Bromobenzaldehyde → E-4-bromostyryl 4-fluorobenzyl sulfone

反応式

[F:1][C:2]1[CH:15]=[CH:14][C:5]([CH2:6][S:7]([CH2:10][C:11](O)=O)(=[O:9])=[O:8])=[CH:4][CH:3]=1.[Br:16][C:17]1[CH:24]=[CH:23][C:20](C=O)=[CH:19][CH:18]=1>>[F:1][C:2]1[CH:15]=[CH:14][C:5]([CH2:6][S:7](/[CH:10]=[CH:11]/[C:20]2[CH:23]=[CH:24][C:17]([Br:16])=[CH:18][CH:19]=2)(=[O:9])=[O:8])=[CH:4][CH:3]=1

参加物

反応物 2

HCID 707414-Bromobenzaldehyde

HCID 11447598[(4-Fluorobenzyl)sulfonyl]acetic acid

生成物 1

HCID 9798714E-4-bromostyryl 4-fluorobenzyl sulfone収率 82%

実験手順

A solution of 4-fluorobenzyl sulfonylacetic acid (0.01 mol) and 4-bromobenzaldehyde (0.01 mol) was subjected to Procedure 1, Part B. The title compound was obtained in 82% yield.

出典と根拠

ORDレコード: ord-a716a7fd8f49480381302b303a38342a
出典データセット: uspto-grants-2003_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06656973B2

反応ノート

読み込み中…