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Acetyl chloride → N-Butyl-N-[5-(2-chloro-6-fluorophenyl)-imidazo[1,2-b][1,2,4]triazol-6-yl]-acetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetyl chloride | HCID 6367 | — |
| 反応物 | 2-Chloro-6-fluorobenzaldehyde | HCID 67847 | — |
| 反応物 | Butyl isocyanide | HCID 76008 | — |
| 反応物 | HCID 178418311 | HCID 178418311 | — |
| 溶媒 | Perchloric Acid | HCID 24247 | — |
| 生成物 | N-Butyl-N-[5-(2-chloro-6-fluorophenyl)-imidazo[1,2-b][1,2,4]triazol-6-yl]-acetamide | HCID 22335588 | — |
反応手順
Compound 55 was prepared in accordance with the general synthesis instructions from 1.0 ml (0.1 mmol) 3-amino-1,2,4-triazole solution (0.1 M, MC), 0.575 ml (0.115 mmol) n-butylisonitrile solution (0.2 M, MC), 0.500 ml (0.15 mmol) 2-chloro-6-fluorobenzaldehyde solution (0.3 M, MC) and 10 μl perchloric acid (w=20%) and by reaction with acetyl chloride, the excess acetyl chloride being removed in vacuo.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06657064B2 |
| 出典データセット | uspto-grants-2003_12 |
| ORD ID | ord-0878b30f5d244b1aa6b435ecbb45aa6c |
| 出典メモ | uspto-grants-2003_12 |