Water → 1-(4-Bromo-1,3-thiazol-2-YL)piperidine
反応式
[N:1]1([C:7]2[S:8][CH:9]=[C:10]([Sn](C)(C)C)[N:11]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[Br:16]C1SC=C(Br)N=1.O>N1CCCCC1>[N:1]1([C:7]2[S:8][CH:9]=[C:10]([Br:16])[N:11]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1参加物
5
反応条件
- 温度
- 50 °C
実験手順
Synthesis of 2-Piperidinyl-4-(trimethylstannyl)thiazole 373 as illustrated in FIG. 53. 2,4-Dibromothiazole (358; 1.0 equiv) was dissolved in piperidine (0.5 M) and the reaction was warmed to 50° C. for 8 h, upon which completion of the reaction was indicated by TLC. The mixture was poured into water and extracted with ether (2×). Drying (MgSO4) and evaporation of the solvents gave 2-piperidinyl-4-bromothiazole 372, which was isolated after flash column chromatography (silica gel, 5% EtOAc in hexanes) in 100% yield.
後処理
- extractionextracted with ether (2×)
- customDrying
- custom(MgSO4) and evaporation of the solvents
出典と根拠
- ORDレコード
- ord-c9683db9457148338af7a6e8a9b0c8ca
- 出典データセット
- uspto-grants-2003_12
- 特許番号
- US06660758B1
反応ノート
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