化工社化工社 化学情報印刷レポート · 研究参考用
Potassium Fluoride → 2-Cyano-3-fluoropyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Fluoride | HCID 522689 | — |
| 反応物 | 3-Chloropyridine-2-carbonitrile | HCID 818258 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 溶媒 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 生成物 | 2-Cyano-3-fluoropyridine | HCID 7060408 | 50.1% |
反応手順
A solution of 2-cyano-3-chloropyridine (1 g, 7.22 mmol) in 1-methyl-2-pyrrolidinone (25 mL) was treated with potassium fluoride (1.26 g, 21.68 mmol) and heated at reflux for 18 hours. After cooling, the reaction was diluted with ethyl acetate and extracted with water and brine. Silica gel chromatography afforded 442 mg (50%) of 2-cyano-3-fluoropyridine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06660753B2 |
| 出典データセット | uspto-grants-2003_12 |
| ORD ID | ord-014da495d5b5402d8cbd5806a0c66b61 |
| 出典メモ | uspto-grants-2003_12 |