Hydrochloric Acid → Methyl 3-bromo-5-iodobenzoate
反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([I:11])[CH:10]=1)[C:5]([OH:7])=[O:6].Cl.[CH3:13]O>C(OCC)C>[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([I:11])[CH:10]=1)[C:5]([O:7][CH3:13])=[O:6]参加物
5
反応条件
- 温度
- 40 °C
実験手順
A mixture of 3-bromo-5-iodobenzoic acid (9.0 g) in methanol (40 mL) was treated with 1M HCl in diethyl ether (27.5 mL). The reaction was heated overnight at 40° C. The solvent was then removed in vacuo, and the residue dissolved in ethyl acetate. The organic solution was washed with saturated sodium bicarbonate, dried over anhydrous sodium sulfate, filtered and concentrated to afford 8.8 g (94%) of methyl 3-bromo-5-iodobenzoate.
後処理
- customThe solvent was then removed in vacuo
- dissolutionthe residue dissolved in ethyl acetate
- washThe organic solution was washed with saturated sodium bicarbonate
- dry with materialdried over anhydrous sodium sulfate
- filtrationfiltered
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-94a49d8695bb478ca21b31926b752853
- 出典データセット
- uspto-grants-2003_12
- 特許番号
- US06660753B2
反応ノート
読み込み中…