Hydrochloric Acid → Methyl 3-bromo-5-iodobenzoate

HRID 431856

反応式

HRID 431856 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([I:11])[CH:10]=1)[C:5]([OH:7])=[O:6].Cl.[CH3:13]O>C(OCC)C>[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([I:11])[CH:10]=1)[C:5]([O:7][CH3:13])=[O:6]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 51825203-Bromo-5-iodobenzoic acid

生成物 1

HCID 21942573Methyl 3-bromo-5-iodobenzoate収率 94%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

反応条件

温度
40 °C

実験手順

A mixture of 3-bromo-5-iodobenzoic acid (9.0 g) in methanol (40 mL) was treated with 1M HCl in diethyl ether (27.5 mL). The reaction was heated overnight at 40° C. The solvent was then removed in vacuo, and the residue dissolved in ethyl acetate. The organic solution was washed with saturated sodium bicarbonate, dried over anhydrous sodium sulfate, filtered and concentrated to afford 8.8 g (94%) of methyl 3-bromo-5-iodobenzoate.

後処理

  1. customThe solvent was then removed in vacuo
  2. dissolutionthe residue dissolved in ethyl acetate
  3. washThe organic solution was washed with saturated sodium bicarbonate
  4. dry with materialdried over anhydrous sodium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-94a49d8695bb478ca21b31926b752853
出典データセット
uspto-grants-2003_12
特許番号
US06660753B2

関連ノート

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