Water → 4-Amino-3-bromo-5-(trifluoromethoxy)benzoic acid

HRID 431873ノート

反応式

HRID 431873 の反応式
[NH2:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=1[O:11][C:12]([F:15])([F:14])[F:13].[Br:16]Br.O>C(O)(=O)C>[NH2:1][C:2]1[C:3]([O:11][C:12]([F:13])([F:14])[F:15])=[CH:4][C:5]([C:6]([OH:8])=[O:7])=[CH:9][C:10]=1[Br:16]

参加物

5

反応物 3

HCID 962WaterHCID 24408BromineHCID 27359514-amino-3-(trifluoromethoxy)benzoic Acid

生成物 1

HCID 219424074-Amino-3-bromo-5-(trifluoromethoxy)benzoic acid収率 57.5%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒2 回

実験手順

To a solution of 4-amino-3-trifluoromethoxybenzoic acid (5 g, 22.6 mmoles) in acetic acid (50 mL), bromine(3.98 g, 24.9 mmoles) in acetic acid(10 mL) was added dropwise at room temperature. After the reaction mixture was kept stirring for one hour, water was added into the mixture. The solid was filtered and washed with water to give 4-amino-3-bromo-5-trifluoromethoxybenzoic acid (3.9 g, 54.9%).

後処理

  1. filtrationThe solid was filtered
  2. washwashed with water

出典と根拠

ORDレコード
ord-2ca0e522c37f40aeba58016934a2063d
出典データセット
uspto-grants-2003_12
特許番号
US06660753B2

反応ノート

読み込み中…