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Dimethylformamide → 3-(Pyridin-2-yl)-5-(5-chloro-pyrid-3-yl)-1,2,4-oxadiazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 5-Chloronicotinic acid | HCID 247986 | — |
| 反応物 | 5-Chloronicotinoyl chloride | HCID 21942649 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 3-(Pyridin-2-yl)-5-(5-chloro-pyrid-3-yl)-1,2,4-oxadiazole | HCID 9856474 | — |
反応手順
In a similar fashion, 5-chloronicotinoyl chloride was prepared from 5-chloronicotinic acid (157 mg, 1 mmol). Treatment of the acid chloride with pyrid-2-ylamidoxime (137 mg, 1 mmol) and triethylamine (404 mg, 4 mmol) in dichloromethane (2 mL), followed by heating in dimethylformamide (2 mL) at 120° C. for 3 hours afforded 149 mg (58%) of 3-(2-pyridyl)-5-(5-chloro-pyrid-3-yl)-1,2,4-oxadiazole (149 mg, 57.6%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06660753B2 |
| 出典データセット | uspto-grants-2003_12 |
| ORD ID | ord-1d82863d148c459884d8b013a31796a2 |
| 出典メモ | uspto-grants-2003_12 |