tert-Butyl piperazine-1-carboxylate → Tert-butyl 4-(2-methylpyridin-3-yl)piperazine-1-carboxylate

温度

100 °C

Palladium acetate (65 mg, 0.29 mmol) and RuPhos (271mg, 0.58mmol) were dissolved in toluene (10 mL), degassed and purged with nitrogen and warmed to 50°C for 15 minutes. In a separate vessel, were mixed 3-bromo-2-methyl pyridine (1.00g, 5.81 mmol), BOC-piperazine (1.08g, 5.81mmol), sodium tertbutoxide and toluene (17 mL). The mixture was degassed, purged with nitrogen and warmed to 50°C. The catalyst was transferred to the reaction vessel and the mixture degassed and purged with nitrogen. The reaction was heated at 100°C overnight under nitrogen. The mixture was filtered through GF/F paper, washing with MeOH. The filtrate was concentrated to provide a dark brown gum. The gum was purified by flash silica chromatography, elution gradient 30 to 80% EtOAc in heptane. Pure fractions were evaporated to provide the desired product as a gum (1.492g, 93%). Rf (1:1 EtOAc/heptane) 0.3

ORDレコード

ord-316cf52c137541f4a2a9960bf7cb84d3

出典データセット

750 AstraZeneca ELN dataset

元リンク

出典を表示