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Piperazine → Piperazine,1-[4-(4-chlorophenyl)butyl]-
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Piperazine | HCID 4837 | — |
| 反応物 | 1-Chloro-4-(4-chlorobutyl)benzene | HCID 20082732 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | Piperazine,1-[4-(4-chlorophenyl)butyl]- | HCID 14097058 | 46.3% |
反応手順
A mixture of 26.4 g of 4-(4-chlorophenyl)butyl chloride, 86.1 g of anhydrous piperazine and 250 ml of reagent ethanol was refluxed overnight. Solvent was evaporated from the product and the residue was chromatographed twice on silica with the eluant being CH2Cl2 /CH3OH/ammonium hydroxide (45:5:1). The first chromatography removed the bulk of the excess piperazine, the second provided 15.2 g of 1-[4-(4-chlorophenyl)butyl]piperazine as a colorless oil which solidified on standing (m.p. 139°-145° C.).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04725597 |
| 出典データセット | uspto-grants-1988_02 |
| ORD ID | ord-81005d9a5e474ae9811ee087317133f2 |
| 出典メモ | uspto-grants-1988_02 |