Ethanol → Ethyl 3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate

HRID 43230

反応式

HRID 43230 の反応式
[CH2:1]([C:3]([CH2:8][OH:9])([CH3:7])[C:4]([OH:6])=[O:5])[OH:2].[CH2:10](O)[CH3:11]>>[CH2:1]([C:3]([CH2:8][OH:9])([CH3:7])[C:4]([O:6][CH2:10][CH3:11])=[O:5])[OH:2]

参加物

3

反応物 2

HCID 702EthanolHCID 78501Dimethylolpropionic acid

生成物 1

HCID 23370761Ethyl 3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate

実験手順

2,2-bis(methylol)propionic acid (bis-MPA) (22.1 g, 0.165 mol) was added in ethanol (150 mL) with Amberlyst-15 (6.8 g) and refluxed overnight. The resins were then filtered out and the filtrate was evaporated. Methylene chloride (200 mL) was added to the resulting viscous liquid to filter the unreacted reagent and by-products. The solution was dried over Mg504, filtered, and the solvent was removed in vacuo. Ethyl 2,2-bis(methylol)propionate was obtained as a clear and colorless liquid (21.1 g, 86% yield).

後処理

  1. temperaturerefluxed overnight
  2. filtrationThe resins were then filtered out
  3. customthe filtrate was evaporated
  4. additionMethylene chloride (200 mL) was added to the resulting viscous liquid
  5. filtrationto filter the unreacted reagent and by-products
  6. customThe solution was dried over Mg504
  7. filtrationfiltered
  8. customthe solvent was removed in vacuo

出典と根拠

ORDレコード
ord-1bf505e21da74291b496869102b38a9a
出典データセット
uspto-grants-2013_09
特許番号
US08536291B2

関連ノート

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