Methyl trifluoroacetate → 2,2,2-trifluoro-N-(prop-2-yn-1-yl)acetamide

HRID 43233

反応式

HRID 43233 の反応式
[CH2:1]([NH2:4])[C:2]#[CH:3].[F:5][C:6]([F:12])([F:11])[C:7](OC)=[O:8]>>[CH2:1]([NH:4][C:7](=[O:8])[C:6]([F:12])([F:11])[F:5])[C:2]#[CH:3]

参加物

3

反応物 2

HCID 9893Methyl trifluoroacetateHCID 239041Propargylamine

生成物 1

HCID 110948052,2,2-trifluoro-N-(prop-2-yn-1-yl)acetamide収率 87.4%

反応条件

温度
0 °C

実験手順

Propargyl amine (4.00 g, 72.62 mmol, 1.00 equiv.) was added dropwise to methyl trifluoroacetate (11.16 g, 87.15 mmol, 1.20 equiv.) at 0° C. The reaction mixture was stirred at 0° C. for 2 h and then concentrated under reduced pressure to remove methanol. The product was purified by vacuum distillation yielding propargyltrifluoroacetamide as a colorless liquid (9.59 g, 87%). The structure was confirmed by 1H- and 19F-NMR.

後処理

  1. concentrationconcentrated under reduced pressure
  2. customto remove methanol
  3. distillationThe product was purified by vacuum distillation

出典と根拠

ORDレコード
ord-0c87ca0e49aa4225a4f05950478c040b
出典データセット
uspto-grants-2013_09
特許番号
US08536323B2

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