Potassium Carbonate → 2,2-Dimethyl-3-(4-pyridin-3-yl-imidazol-1-yl)-propanol

HRID 432572ノート

反応式

HRID 432572 の反応式
C([O:4][CH2:5][C:6]([CH3:20])([CH3:19])[CH2:7][N:8]1[CH:12]=[C:11]([C:13]2[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=2)[N:10]=[CH:9]1)(=O)C.C([O-])([O-])=O.[K+].[K+]>CO>[CH3:19][C:6]([CH3:20])([CH2:7][N:8]1[CH:12]=[C:11]([C:13]2[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=2)[N:10]=[CH:9]1)[CH2:5][OH:4]

参加物

4

反応物 2

HCID 11430Potassium CarbonateHCID 545188152,2-Dimethyl-3-(4-pyridin-3-yl-imidazol-1-yl)-propyl acetate

生成物 1

HCID 187597722,2-Dimethyl-3-(4-pyridin-3-yl-imidazol-1-yl)-propanol

試薬・触媒・溶媒 1

HCID 887Methanol溶媒2 回

実験手順

To a solution of 2,2-Dimethyl-3-(4-pyridin-3-yl-imidazol-1-yl)-propyl acetate (20 mg) in methanol was added saturated solution of K2CO3 in metanol (1.5 mL) and the resulting solution was stirred at room temperature for 1 hour. MeOH was evaporated in vacuo and water was added followed by CH2Cl2. The aqueous layer was extracted with CHCl3, the combined organic layers were washed with brine, dried over Na2SO4 and evaporated in vacuo to afford the title compound as a slightly yellow oil.

後処理

  1. customMeOH was evaporated in vacuo and water
  2. additionwas added
  3. extractionThe aqueous layer was extracted with CHCl3
  4. washthe combined organic layers were washed with brine
  5. dry with materialdried over Na2SO4
  6. customevaporated in vacuo

出典と根拠

ORDレコード
ord-8501f40c84da40fcb82da15640b238aa
出典データセット
uspto-grants-2003_12
特許番号
US06664238B1

反応ノート

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