Triacetoxyperiodinane → 2,2-Dimethyl-3-(4-pyridin-3-yl-imidazol-1-yl)-propioaldehyde

HRID 432573ノート

反応式

HRID 432573 の反応式
[CH3:1][C:2]([CH3:17])([CH2:5][N:6]1[CH:10]=[C:9]([C:11]2[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=2)[N:8]=[CH:7]1)[CH2:3][OH:4].CC(OI1(OC(C)=O)(OC(C)=O)OC(=O)C2C=CC=CC1=2)=O.C([O-])(O)=O.[Na+]>C(Cl)Cl>[CH3:1][C:2]([CH3:17])([CH2:5][N:6]1[CH:10]=[C:9]([C:11]2[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=2)[N:8]=[CH:7]1)[CH:3]=[O:4]

参加物

5

反応物 3

HCID 159087TriacetoxyperiodinaneHCID 516892Sodium BicarbonateHCID 187597722,2-Dimethyl-3-(4-pyridin-3-yl-imidazol-1-yl)-propanol

生成物 1

HCID 187597702,2-Dimethyl-3-(4-pyridin-3-yl-imidazol-1-yl)-propioaldehyde

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of 2,2-Dimethyl-3-(4-pyridin-3-yl-imidazol-1-yl)-propanol (11 mg) in CH2Cl2 was added Dess-Martin periodinane (41 mg) and the resulting solution was stirred at room temperature for 15 minutes. Saturated NaHCO3 was added, the aqueous layer was extracted with CHCl3, the combined organic layers were washed with brine, dried over Na2SO4 and evaporated in vacuo to afford the title compound as a slightly yellow oil.

後処理

  1. extractionthe aqueous layer was extracted with CHCl3
  2. washthe combined organic layers were washed with brine
  3. dry with materialdried over Na2SO4
  4. customevaporated in vacuo

出典と根拠

ORDレコード
ord-324e5c4dc50846dbadca52ec4dc1eecf
出典データセット
uspto-grants-2003_12
特許番号
US06664238B1

反応ノート

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