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3-Methylbut-1-yne → 6-Methoxy-4-(3-methylbut-1-ynyl)pyridin-3-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Methylbut-1-yne | HCID 69019 | — |
| 反応物 | 4-Iodo-6-methoxypyridin-3-amine | HCID 11021287 | — |
| 触媒 | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| 触媒 | HCID 178418476 | HCID 178418476 | — |
| 溶媒 | Triethylamine | HCID 8471 | — |
| 生成物 | 6-Methoxy-4-(3-methylbut-1-ynyl)pyridin-3-amine | HCID 58025065 | — |
反応手順
To a solution of 4-iodo-6-methoxypyridin-3-amine (Compound 3, 845 mg, 3.4 mmol) in Et3N (12 ml) in a re-sealable pressure tube was added Pd(PPh3)2Cl2 (24 mg, 0.034 mmol), CuI (7.0 mg, 0.034 mmol), and 3-methyl-1-butyne (0.66 ml, 6.8 mmol). The mixture was stirred at room temperature for 20 h and the solvent was removed in vacuo. The residue was purified by chromatography on silica gel (0→30% EtOAc-hexanes) to yield the title compound as beige solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08536339B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-deb59c03055b4bb29d9d3f2aa34398ad |
| 出典メモ | uspto-grants-2013_09 |