2,5-Difluorophenol → 3,4-Bis(4-methoxyphenyl)-6-(2,5-difluorophenoxy)pyridazine

HRID 432624ノート

反応式

HRID 432624 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:10]=[N:11][C:12](Cl)=[CH:13][C:14]=2[C:15]2[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=2)=[CH:5][CH:4]=1.[F:24][C:25]1[CH:30]=[CH:29][C:28]([F:31])=[CH:27][C:26]=1[OH:32]>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:10]=[N:11][C:12]([O:32][C:26]3[CH:27]=[C:28]([F:31])[CH:29]=[CH:30][C:25]=3[F:24])=[CH:13][C:14]=2[C:15]2[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=2)=[CH:5][CH:4]=1

参加物

3

反応物 2

HCID 949522,5-DifluorophenolHCID 125680843,4-Bis(4-methoxyphenyl)-6-chloropyridazine

生成物 1

HCID 102956223,4-Bis(4-methoxyphenyl)-6-(2,5-difluorophenoxy)pyridazine

実験手順

In a similar manner as in Example 2, 3,4-bis(4-methoxyphenyl)-6-chloropyridazine (200 mg, 0.613 mmol) and 2,5-difluorophenol were reacted as starting materials at 150° C. for 24 hours and post-treatment was then conducted, whereby the title compound was obtained as a colorless crystalline powder (235.5 mg, 91.5%). Melting point: 174.4-175.2° C. (chloroform-hexane).

後処理

  1. customat 150° C.
  2. customfor 24 hours

出典と根拠

ORDレコード
ord-92e8f13b173646d68425a0b293925364
出典データセット
uspto-grants-2003_12
特許番号
US06664256B1

反応ノート

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