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Acetic Acid → 4-Benzylidenehomophthalimide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | Benzaldehyde | HCID 240 | — |
| 反応物 | Piperidine | HCID 8082 | — |
| 反応物 | 1,3(2H,4H)-isoquinolinedione | HCID 349435 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 4-Benzylidenehomophthalimide | HCID 131724257 | 82% |
反応手順
A stirred mixture of homophthalimide (15 g, 93 mmol), benzaldehyde (9.9 g, 93 mmol), piperidine (9 ml) and acetic acid (465 ml) was heated under reflux for 1 hour, cooled to ambient temperature and diluted with water (500 ml). The resulting solid was collected by filtration, washed with water and dried in vacuo to give 4-benzylidenehomophthalimide (18.5 g, 82%) as a solid; m.pt. 173-177° C. Used crude for the next step.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06664269B2 |
| 出典データセット | uspto-grants-2003_12 |
| ORD ID | ord-3ed1c6bb572346d38519790eb429ae25 |
| 出典メモ | uspto-grants-2003_12 |