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1-Butanol → n-Butyl 1-benzoyl-3-piperidinecarboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Butanol | HCID 263 | — |
| 反応物 | 1-Benzoylpiperidine-3-carboxylic acid | HCID 3136474 | — |
| 反応物 | Ethyl 1-(3-thiophenecarbonyl)-3-piperidinecarboxylate | HCID 12114708 | — |
| 生成物 | n-Butyl 1-benzoyl-3-piperidinecarboxylate | HCID 53869174 | — |
反応手順
The reaction was run in the same manner as ethyl 1-(3-thiophenecarbonyl)-3-piperidinecarboxylate, starting with 1-benzoyl-3-piperidine carboxylic acid (500 mg; 2.1 mmol) and commercially available n-butanol (500 μl; 5.5 mmol). The crude product was distilled at 225° C./0.1 torr, giving n-butyl 1-benzoyl-3-piperidinecarboxylate (258.2 mg) as a light yellow oil. MS m/z (positive ion) 312 (M+Na+; 75), 290 (NH+; 100).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06664271B1 |
| 出典データセット | uspto-grants-2003_12 |
| ORD ID | ord-0217d07fab2f45c7a9c830dcd14a8100 |
| 出典メモ | uspto-grants-2003_12 |