化工社化工社 化学情報印刷レポート · 研究参考用
Benzoyl chloride → (S)-ethyl 1-benzoyl-3-piperidinecarboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzoyl chloride | HCID 7412 | — |
| 反応物 | Ethyl (3S)-piperidine-3-carboxylate | HCID 187784 | — |
| 反応物 | Ethyl 1-benzoyl-3-piperidinecarboxylate | HCID 3784394 | — |
| 生成物 | (S)-ethyl 1-benzoyl-3-piperidinecarboxylate | HCID 670251 | — |
反応手順
The reaction was run in the same manner as ethyl 1-benzoyl-3-piperidinecarboxylate, starting with commercially available (S)-ethyl nipecotate (203 mg; 1.29 mmol; Chemi SpA; Italy) and benzoyl chloride (150 μl; 1.29 mmol). The crude product was distilled at 200° C./0.1 torr, giving (S)-ethyl 1-benzoyl-3-piperidinecarboxylate (171.7 mg) as a colorless oil. MS m/z (positive ion) 545 (dimer+Na+; 15), 523 (dimer+; 10), 284 (M+Na+; 25), 262 (MH+; 100).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06664271B1 |
| 出典データセット | uspto-grants-2003_12 |
| ORD ID | ord-52557d95f02e4990bcaf292be7e47464 |
| 出典メモ | uspto-grants-2003_12 |