化工社化工社 化学情報印刷レポート · 研究参考用
2-Thiopheneacetyl chloride → Ethyl 1-(2-thiopheneacetyl)-3-piperidinylacetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Thiopheneacetyl chloride | HCID 162362 | — |
| 反応物 | Ethyl 2-(piperidin-3-yl)acetate | HCID 2760464 | — |
| 反応物 | Ethyl 1-benzoyl-3-piperidinecarboxylate | HCID 3784394 | — |
| 生成物 | Ethyl 1-(2-thiopheneacetyl)-3-piperidinylacetate | HCID 70028632 | 51.3% |
反応手順
The reaction was run in the same manner as ethyl 1-benzoyl-3-piperidinecarboxylate, starting with ethyl 3-piperidinylacetate (414.2 mg; 2.4 mmol) and 2-thiopheneacetyl chloride (295 μl; 2.4 mmol). The crude product was purified by chromatography on silica, eluting with 50% ethyl acetate in hexane, giving ethyl 1-(2-thiopheneacetyl)-3-piperidinylacetate (364 mg) as a pale yellow oil. MS m/z (positive ion) 318 (M+Na+; 40), 296 (MH+; 100).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06664271B1 |
| 出典データセット | uspto-grants-2003_12 |
| ORD ID | ord-be5956bf8df3460aac0e9726e6384575 |
| 出典メモ | uspto-grants-2003_12 |