化工社化工社 化学情報印刷レポート · 研究参考用
Sodium Hydroxide → (S)-1-benzoyl-3-piperidinecarboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | (S)-ethyl 1-benzoyl-3-piperidinecarboxylate | HCID 670251 | — |
| 反応物 | 1-(2-(Thiophen-2-yl)acetyl)piperidine-3-carboxylic acid | HCID 16790995 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | (S)-1-benzoyl-3-piperidinecarboxylic acid | HCID 743141 | 92.7% |
反応手順
The reaction was run in the same manner as 1-(2-thiopeneacetyl)-3-piperidine carboxylic acid, starting with (S)-ethyl 1-benzoyl-3-piperidinecarboxylate (8.71 g; 33.31 mmol), 1N sodium hydroxide (100 ml) and absolute ethanol (100 ml), giving (S)-1-benzoyl-3-piperidinecarboxylic acid as a white solid (7.20 g). MS m/z (negative ion) 232 ([M-H]−; 100).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06664271B1 |
| 出典データセット | uspto-grants-2003_12 |
| ORD ID | ord-e75c0336ea6648c4ad4215840a5bc935 |
| 出典メモ | uspto-grants-2003_12 |