反応式
[ClH:1].CO[C:4](=[O:27])/[CH:5]=[CH:6]/[C:7]1C=CC(CNCCC2[C:25]3[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=3)[NH:19]C=2C)=CC=1.[CH3:28]C1NC2C(=CC=CC=2)C=1CC[NH2:33]>C(O)C>[C:20]1([NH:19][NH2:33])[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.[Cl:1][CH2:7][CH2:6][CH2:5][C:4](=[O:27])[CH3:28]参加物
5
実験手順
The third embodiment of the present invention is directed to a method of making a starting material useful in the synthesis of (E)-3-(4-{[2-(2-methyl-1H-indol-3-yl)-ethylamino]-methyl]-phenyl)-acrylic acid methyl ester hydrochloride salt. In particular, the third embodiment of the present invention is directed to a method of making 2-methyltryptamine comprising the steps of: (a) providing an admixture of phenylhydrazine and 5-chloro-2-pentanone in ethanol at a first temperature; (b) adding ethanol to the admixture and refluxing the mixture; (c) distilling ethanol; (d) adding water to the residual solution; (e) cooling the residual solution to form 2-methyltryptamine.
出典と根拠
- ORDレコード
- ord-e45d2870354b41a69e22a30e69c1897b
- 出典データセット
- uspto-grants-2013_09
- 特許番号
- US08536346B2
関連ノート
読み込み中…