Nitromethane → 2-Methoxy-11-[2-nitroethenyl]-6h-pyrido[2',3':4,5]pyrrolo[2,1-a]-isoindole
反応式
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[N:10]3[CH2:11][C:12]4[C:17]([C:9]3=[C:8]([CH:18]=O)[C:7]=2[N:20]=1)=[CH:16][CH:15]=[CH:14][CH:13]=4.C([O-])(=O)C.[NH4+].[N+:26]([CH3:29])([O-:28])=[O:27]>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[N:10]3[CH2:11][C:12]4[C:17]([C:9]3=[C:8]([CH:18]=[CH:29][N+:26]([O-:28])=[O:27])[C:7]=2[N:20]=1)=[CH:16][CH:15]=[CH:14][CH:13]=4参加物
4
実験手順
600 mg (2.27 mmol) of the compound obtained in Step E dissolved in 25 ml of nitromethane are heated at 120° C., for 3 hours in the presence of 440 mg (5.67 mmol) of ammonium acetate. After returning to room temperature and evaporation to dryness, the reaction mixture is diluted in dichloromethane and washed with water. After drying over magnesium sulphate, evaporation of the organic phase yields the title compound in the form of a yellow solid.
後処理
- customAfter returning to room temperature
- customevaporation to dryness
- additionthe reaction mixture is diluted in dichloromethane
- washwashed with water
- dry with materialAfter drying over magnesium sulphate, evaporation of the organic phase
出典と根拠
- ORDレコード
- ord-dd041773c39f4f20a5cececd4924bd10
- 出典データセット
- uspto-grants-2003_12
- 特許番号
- US06667304B2
反応ノート
読み込み中…