Potassium Carbonate → 3-Benzyl-2-cyclopentenol

HRID 433094ノート

反応式

HRID 433094 の反応式
[CH2:1]([C:8]1[CH2:12][CH2:11][C:10](=[O:13])[CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-].C([O-])([O-])=O.[K+].[K+]>CCOCC>[CH2:1]([C:8]1[CH2:12][CH2:11][CH:10]([OH:13])[CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 118299173-Benzylcyclopent-2-en-1-oneHCID 21226445Aluminium lithium hydride

生成物 1

HCID 121097083-Benzyl-2-cyclopentenol収率 95.7%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒2 回

実験手順

A solution of compound 3-benzyl-2-cyclopenten-1-one (3.1 g, 18 mmol) in ether (100 mL) was slowly added to a suspension of lithium aluminum hydride (LAH) (684 mg, 0.87 mol) and ether (100 mL) at 0° C. under N2. The resulting mixture was stirred overnight at ambient temperature and cooled to 0° C. Saturated K2CO3 solution was added to quench the excess LAH, the mixture was filtered through Celite and washed with several portions of ether. The combined organic layers were dried (MgSO4) and concentrated in vacuo to give compound the title compound (3 g, 94%) as a colorless oil.

後処理

  1. temperaturecooled to 0° C
  2. customto quench the excess LAH
  3. filtrationthe mixture was filtered through Celite
  4. washwashed with several portions of ether
  5. dry with materialThe combined organic layers were dried (MgSO4)
  6. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-253a2461d8364af38fab8a057093201d
出典データセット
uspto-grants-2003_12
特許番号
US06667309B2

反応ノート

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