Chloroform → 2-amino-N-(2-chlorophenyl)-5-hydroxybenzamide

関与物質

役割	名称	HCID	仕込み量
反応物	Chloroform	HCID 6212	—
反応物	2-Chloroaniline	HCID 7240	—
反応物	Thionyl Chloride	HCID 24386	—
反応物	5-Hydroxyanthranilic acid	HCID 164592	—
溶媒	Benzene	HCID 241	—
生成物	2-amino-N-(2-chlorophenyl)-5-hydroxybenzamide	HCID 22316564	12%

反応手順

Prepared according to Procedure A using 2-amino-5-hydroxybenzoic acid (5.0 g, 32.7 mmol) and SOCl2 (6.0 mL, 81.6 mmol) in benzene (150 mL), followed by 2-chloroaniline (6.9 mL, 65.4 mmol) and CHCl3 (150 mL). The product was purified by two chromatographies in MeOH/CH2Cl2 to provide 990 mg of a brown solid (12%). 1H NMR (MeOH-d4) δ: 7.92 (dd, J=1.6, 8.1 Hz, 1H); 7.48 (dd, J=1.5, 7.7 Hz, 1H); 7.34 (dt, J=1.5, 7.7 Hz, 1H); 7.20 (dt, J=1.7, 7.7 Hz, 1H); 7.16 (d, J=2.7 Hz, 1H); 6.83 (dd, J=2.7, 8.7 Hz, 1H); 6.76 (d, J=8.7 Hz, 1H); [6.24 (br s, 2H)). MS (ES): m/z 263.0 (M+).

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US06667300B2
出典データセット	uspto-grants-2003_12
ORD ID	ord-ab30ca18b73141689e84ed1002d9df2b
出典メモ	uspto-grants-2003_12