Chloroacetyl chloride → 5-Chloro-2-chloromethyl-3-(2-fluorophenyl)-3H-quinazolin-4-one

関与物質

役割	名称	HCID	仕込み量
反応物	Chloroacetyl chloride	HCID 6577	—
反応物	2-amino-6-chloro-N-(2-fluorophenyl)benzamide	HCID 22316580	—
溶媒	Acetic Acid	HCID 176	—
生成物	5-Chloro-2-chloromethyl-3-(2-fluorophenyl)-3H-quinazolin-4-one	HCID 22316557	40%

反応手順

Prepared according to Procedure B with 1k (1.0 g, 3.78 mmol) and chloroacetyl chloride (0.90 mL, 11.3 mmol) in acetic acid (20 mL). Purified by chromatography in CH2Cl2 to afford 484 mg of a pale pink solid (40%). 1H NMR (CDCl3) δ: 7.69 (s, 1H); 7.68 (d, J=3.2 Hz, 1H); 7.56 (d, J=3.0 Hz, 1H); 7.54 (d, J=3.0 Hz, 1H); 7.40-7.47 (m, 1H); 7.35-7.38 (m, 1H); 7.27-7.32 (m, 1H); 4.35 (d, J=12 Hz, 1H); 4.18 (d, J=12 Hz, 1H). MS (ES): m/z 323.0 (M+).

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US06667300B2
出典データセット	uspto-grants-2003_12
ORD ID	ord-e3ca44bd8e1e47ff9c1b17b070c90c1b
出典メモ	uspto-grants-2003_12