化工社化工社 化学情報印刷レポート · 研究参考用
Citric Acid → Formoterol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Citric Acid | HCID 311 | — |
| 反応物 | Sodium Chloride | HCID 5234 | — |
| 反応物 | Trisodium citrate | HCID 6224 | — |
| 反応物 | (E)-but-2-enedioic acid N-[2-hydroxy-5-[1-hydroxy-2-[1-(4-methoxyphenyl)propan-2-ylamino]ethyl]phenyl]formamide dihydrate | HCID 11954385 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Formoterol | HCID 3410 | — |
反応手順
To a 5 L stainless steel vessel were added 0.68 g citric acid USP, 1.99 g sodium citrate USP, and 17.5 g sodium chloride USP. Purified water USP (2 L) was added to the stainless steel vessel and the contents were mixed with an overhead stirrer at a speed of 240 rpm for 10 minutes. Formoterol fumarate dihydrate (0.17 g for low dosage strength formulation, 0.34 g for high dosage strength formulation) was added and the solution was stirred at 240 rpm for 90 minutes.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06667344B2 |
| 出典データセット | uspto-grants-2003_12 |
| ORD ID | ord-6317a0f1cf7b47ee8cb8e7e5955d3cb5 |
| 出典メモ | uspto-grants-2003_12 |