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HRID 433357作成日：2026年10月25日

Homoserine lactone hydrobromide → 3-(N'-(3,5-Difluorophenylacetyl)-L-alaninyl)-amino-gamma-butyrolactone

https://huagongshe.com/reaction/433357

反応式

関与物質

役割名称HCID仕込み量
反応物Homoserine lactone hydrobromideHCID 73508—
反応物(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoic acidHCID 12135350—
生成物3-(N'-(3,5-Difluorophenylacetyl)-L-alaninyl)-amino-gamma-butyrolactoneHCID 86584967—

反応手順

Following General Procedure A above using N-(3,5-difluorophenylacetyl)-L-alanine (Example B) and α-amino-γ-butyrolactone hydrobromide (Aldrich), the title compound was prepared as a solid having a melting point of 174-177° C. The reaction was monitored by tlc on silica gel (Rf=0.52 in 10% methanol/dichloromethane) and purification was by silica gel chromatography.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US06667305B1
出典データセットuspto-grants-2003_12
ORD IDord-f5d98214794b48d881acd85dcb2d2ed8
出典メモuspto-grants-2003_12