(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoic acid → 5-[N'-(3,5-difluorophenylacetyl)-L-alaninyl]amino-7-(methoxyacetyl)-5,7-dihydro-6H-dibenz[b,d]azepin-6-one
反応式
[F:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([NH:12][C@H:13]([C:15]([OH:17])=O)[CH3:14])=[O:11])[CH:5]=[C:6]([F:8])[CH:7]=1.Cl.[NH2:19][N:20]1[C:26](=[O:27])[CH:25]([C:28](=[O:32])[CH2:29][O:30][CH3:31])[C:24]2[CH:33]=[CH:34][CH:35]=[CH:36][C:23]=2[C:22]2[CH:37]=[CH:38][CH:39]=[CH:40][C:21]1=2>>[F:8][C:6]1[CH:5]=[C:4]([CH2:9][C:10]([NH:12][C@H:13]([C:15]([NH:19][N:20]2[C:26](=[O:27])[CH:25]([C:28](=[O:32])[CH2:29][O:30][CH3:31])[C:24]3[CH:33]=[CH:34][CH:35]=[CH:36][C:23]=3[C:22]3[CH:37]=[CH:38][CH:39]=[CH:40][C:21]2=3)=[O:17])[CH3:14])=[O:11])[CH:3]=[C:2]([F:1])[CH:7]=1参加物
3
実験手順
Following General Procedure D and using N-(3,5-difluorophenylacetyl)-L-alanine (Example B) and 5-amino-7-(methoxyacetyl)-5,7-dihydro-6H-dibenz[b,d]azepin-6-one hydrochloride (Example 7-G), the title compound was prepared as a colorless solid. The product was purified by flash chromatography.
後処理
- customThe product was purified by flash chromatography
出典と根拠
- ORDレコード
- ord-b4ee0c1aaf974594ab7a28f83828463e
- 出典データセット
- uspto-grants-2003_12
- 特許番号
- US06667305B1
反応ノート
読み込み中…