Isobutyl pyruvate → N-(4-azidophenyl)alanine Iso-butyl Ester
反応式
[N:1]([C:4]1[CH:10]=[CH:9][C:7]([NH2:8])=[CH:6][CH:5]=1)=[N+:2]=[N-:3].[C:11]([O:16][CH2:17][CH:18]([CH3:20])[CH3:19])(=[O:15])[C:12]([CH3:14])=O>>[CH2:17]([O:16][C:11](=[O:15])[C@H:12]([CH3:14])[NH:8][C:7]1[CH:9]=[CH:10][C:4]([N:1]=[N+:2]=[N-:3])=[CH:5][CH:6]=1)[CH:18]([CH3:20])[CH3:19]参加物
3
実験手順
Following General Procedure AA above and using 4-azidoaniline (Aldrich) and iso-butyl pyruvate (prepared by following General Procedure AO above), the title compound was prepared as an oil. The reaction was monitored by tlc on silica gel (Rf=0.3 in 25% EtOAc/hexanes) and purification was by preparative plate chromatography (silica gel using 25% EtOAc/hexanes as the eluant).
後処理
- customThe reaction was monitored by tlc on silica gel (Rf=0.3 in 25% EtOAc/hexanes) and purification
出典と根拠
- ORDレコード
- ord-44c0e6e43894405cbc0af80e49fefda6
- 出典データセット
- uspto-grants-2003_12
- 特許番号
- US06667305B1
反応ノート
読み込み中…